The Orange County Fire Authority and Newport firefighters were on scene after the crash was reported at 8:16 a.m. Newport Beach and Irvine police also responded.
Two were taken to Western Medical Center-Santa Ana and one was taken to Hoag Memorial Hospital Presbyterian, according to Jennifer Schulz, a spokeswoman for the Newport Beach Fire Department.
The vehicles involved include a gray Lexus sedan, a white Cadillac Escalade and a burgundy Ford Mustang. A fourth car was also involved.
Using special equipment, firefighters removed one person from the Lexus.
According to a witness, the male driver of the Cadillac that overturned was lying on his stomach on the roof, inside the vehicle. He was conscious and able to move his fingers and toes, the witness said. Firefighters had to remove him.
The female driver of the Mustang was not trapped but was also removed by firefighters.